We analyze non-perturbative corrections to the superpotential of seven-brane gauge theories on type IIB and F-theory warped Calabi-Yau compactifications. We show in particular that such corrections modify the holomorphic Yukawa couplings by an exponentially suppressed contribution, generically solving the Yukawa rank-one problem present in F-theory local models. We provide explicit expressions for the non-perturbative correction to the seven-brane superpotential, and check that it is related to a non-commutative deformation to the tree-level superpotential via the Seiberg-Witten map.
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